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CD34單克隆抗體

產(chǎn)品貨號(hào)：

BN42053M
中文名稱：

CD34單克隆抗體
英文名稱：

Mouse anti-CD34 Monoclonal antibody
品牌：

Biorigin

貨號(hào)

產(chǎn)品規(guī)格

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BN42053M-50ul

50ul

￥1486.00

交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-F,IF,ELISA
BN42053M-100ul

100ul

￥2360.00

交叉反應(yīng)：Human 推薦應(yīng)用：WB,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱	CD34
中文名稱	CD34單克隆抗體
別名	CD34 antigen; CD34 molecule; Cluster designation 34; Hematopoietic progenitor cell antigen CD34; HPCA1; CD34_HUMAN; Hematopoietic Stem Cell Marker; Endothelial Markers; Tumor biomarkers.
研究領(lǐng)域	腫瘤心血管細(xì)胞生物干細(xì)胞細(xì)胞粘附分子細(xì)胞表面分子糖蛋白血管內(nèi)皮細(xì)胞
抗體來(lái)源	Mouse
克隆類(lèi)型	Monoclonal
克隆號(hào)	5B4
交叉反應(yīng)	Human,
產(chǎn)品應(yīng)用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	39kDa
細(xì)胞定位	細(xì)胞膜
性狀	Liquid
濃度	1mg/ml
免疫原	Recombinant human CD34 :32-290/385
亞型	IgG
純化方法	affinity purified by Protein A
儲(chǔ) 存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產(chǎn)品介紹	The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence. Hematopoietic Stem Cell Marker Endothelial Markers Tumor biomarkers Function: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. Post-translational modifications: Highly glycosylated. Phosphorylated on serine residues by PKC. Similarity: Belongs to the CD34 family. SWISS: P28906 Gene ID: 947 Database links: Entrez Gene: 947 Human Omim: 142230 Human SwissProt: P28906 Human Unigene: 374990 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.